LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis and Atherosclerosis by Enhancing p53 Activity Running title: Wu et al.; lincRNA-p21 in atherosclerosis
نویسندگان
چکیده
Dept of Cardiology, Chongqing Institute of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, China; Dept of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA; Dept of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China; Dept of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Heath, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA contributed equally
منابع مشابه
LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.
BACKGROUND Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown. METHODS AND RESULTS We identified lincRNA-p21 as a key regulator of cell proliferation and apoptosis during atherosclerosis. The expres...
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